Interferon alpha-2a monotherapy for necrobiotic xanthogranuloma.

oids (5, 6). In our patient the titre of circulating anti-ICS antibodies was low, which might indicate a prolonged initial phase of PV before generalized development of bullae. The massive plasma cell in®ltrate seen in the lesional upper dermis may be a factor for the localization of the lesions. Another possibility is that an unknown mechanism prevents the generalization of PV, resulting in the unique features described above. Since acanthosis was seen histologically, the diagnosis of pemphigus vegetans is also possible.